| General Information of Drug Metabolite (DM) (ID: DM017244) |
| DM Name |
PF-04991532 metabolite M4
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Hydroxylation |
PF-04991532
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| PF-04991532 |
DR3201
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Phase 2 |
Diabetic complication |
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| References |
| 1 |
Metabolism and excretion of (S)-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid (PF-04991532), a hepatoselective glucokinase activator, in humans: confirmation of the MIST potential noted in first-in-Human metabolite scouting studies
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