| General Information of Drug Metabolite (DM) (ID: DM017820) |
| DM Name |
AZD0328 Metabolite M6
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Cytochrome P450 2B6 (CYP2B6)
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DME0020
|
| Oxidation - N-oxidation |
AZD0328
|
[1] |
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Cytochrome P450 2C8 (CYP2C8)
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DME0018
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| Oxidation - N-oxidation |
AZD0328
|
[1] |
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Cytochrome P450 2D6 (CYP2D6)
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DME0009
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| Oxidation - N-oxidation |
AZD0328
|
[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
|
| Oxidation - N-oxidation |
AZD0328
|
[1] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
|
| Oxidation - N-oxidation |
AZD0328
|
[1] |
|
Dimethylaniline oxidase 1 (FMO1)
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DME0059
|
| Oxidation - N-oxidation |
AZD0328
|
[1] |
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Dimethylaniline oxidase 3 (FMO3)
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DME0039
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| Oxidation - N-oxidation |
AZD0328
|
[1] |
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME0021
|
| Oxidation - N-oxidation |
AZD0328
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| AZD0328 |
DR2938
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Discontinued in Phase 2 |
Alzheimer disease |
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| References |
| 1 |
In vitro metabolism of 7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite
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