| General Information of Drug Metabolite (DM) (ID: DM017826) |
| DM Name |
TNP-470 Metabolite MII
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Epoxide hydrolase 1 (EPHX1)
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DME0623
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| Unclear - Unclear |
TNP-470
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[1] |
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| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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UDP-glucuronyltransferase (UGT)
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DMEN064
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| Unclear - Unclear |
TNP-470
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| TNP-470 |
DR2933
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Discontinued in Phase 2 |
Solid tumour/cancer |
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| References |
| 1 |
Phase I dose escalation pharmacokinetics of O-(chloroacetylcarbamoyl) fumagillol (TNP-470) and its metabolites in AIDS patients with Kaposi's sarcoma
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