Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM018064)
DM Name	6-thioguanine nucleotides

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Glutamine amidotransferase (GMPS)	DME0159	6-thioxanthosine-monophosphate	Unclear - Unclear	Azathioprine	[1]
Glutamine amidotransferase (GMPS)	DME0159	6-thioxanthosine monophosphate	Unclear - Unclear	Mercaptopurine	[2] , [3]

Full List of Drug(s) That Produce This DM By Metabolism
Mercaptopurine		DR1031	Approved		Acute lymphoblastic leukemia

Azathioprine		DR0164	Approved		Rheumatoid arthritis

References
1	Gut Microbiota Metabolism of Azathioprine: A New Hallmark for Personalized Drug-Targeted Therapy of Chronic Inflammatory Bowel Disease
2	Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease
3	6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity

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