| General Information of Drug Metabolite (DM) (ID: DM018139) |
| DM Name |
ABT-418 Metabolite M2
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Flavin-containing monooxygenase (FMO)
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DMEN075
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| Unclear - Unclear |
ABT-418
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| ABT-418 |
DR3016
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Discontinued in Phase 2 |
Alzheimer disease |
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| References |
| 1 |
The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans
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| 2 |
In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes). A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation
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