Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM018293)
DM Name	ICI200131

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Aldo-keto reductases (AKR)	DMEN063	Lumateperone tosylate	Reduction - Reduction	lumateperone tosylate	[1]
Aldo-keto reductases (AKR)	DMEN063	ITI-007	Reduction - Reduction	ITI-007	[2]
Ketone reductase (KER)	DMEN804	Lumateperone tosylate	Unclear - Unclear	lumateperone tosylate	[2]

Full List of Drug(s) That Produce This DM By Metabolism
lumateperone tosylate		DR5480	Approved		Schizophrenia

ITI-007		DR3407	Phase 3		Schizophrenia

References
1	Dopamine D(2) receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia
2	An evaluation of lumateperone tosylate for the treatment of schizophrenia

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