Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM018475)
DM Name
ACU-5116
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 2D6 (CYP2D6) DME0009
ACU-5124
Oxidation - Hydroxylation Emixustat [1] , [2]
Cytochrome P450 2D6 (CYP2D6) DME0009
ACU-5149
Oxidation - Hydroxylation Emixustat [1] , [2]
Cytochrome P450 2D6 (CYP2D6) DME0009
ACU-5144
Oxidation - Hydroxylation Emixustat [1] , [2]
Cytochrome P450 2D6 (CYP2D6) DME0009
ACU-5145
Oxidation - Hydroxylation Emixustat [1] , [2]
Cytochrome P450 3A4 (CYP3A4) DME0001
ACU-5124
Oxidation - Hydroxylation Emixustat [1] , [2]
Cytochrome P450 3A4 (CYP3A4) DME0001
ACU-5149
Oxidation - Hydroxylation Emixustat [1] , [2]
Cytochrome P450 3A4 (CYP3A4) DME0001
ACU-5144
Oxidation - Hydroxylation Emixustat [1] , [2]
Cytochrome P450 3A4 (CYP3A4) DME0001
ACU-5145
Oxidation - Hydroxylation Emixustat [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Emixustat DR3375 Phase 2/3 Age-related macular degeneration
References
1 Oxidative Deamination of Emixustat by Human Vascular Adhesion Protein-1/Semicarbazide-Sensitive Amine Oxidase
2 Disposition, profiling and identification of emixustat and its metabolites in humans

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