Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM019426)
DM Name
Minium ion intermediate
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 2C8 (CYP2C8) DME0018
MCN524
Unclear - Unclear Masitinib [1]
Cytochrome P450 2C8 (CYP2C8) DME0018
MCN524
Unclear - Unclear Masitinib [2]
Cytochrome P450 3A4 (CYP3A4) DME0001
MCN524
Unclear - Unclear Masitinib [1]
Cytochrome P450 3A4 (CYP3A4) DME0001
MCN524
Unclear - Unclear Masitinib [2]
Cytochrome P450 3A4 (CYP3A4) DME0001
MCN538
Unclear - Unclear Masitinib [3]
Cytochrome P450 3A5 (CYP3A5) DME0012
MCN538
Unclear - Unclear Masitinib [3]
Full List of Drug(s) That Produce This DM By Metabolism
Masitinib DR3536 Phase 3 Amyotrophic lateral sclerosis
References
1 Corrigendum to: Physiologically-based pharmacokinetic modeling to evaluate in vitro-to-in vivo extrapolation for intestinal P-glycoprotein inhibition
2 Transient and resident pathogens: Intra-facility genetic diversity of Listeria monocytogenes and Salmonella from food production environments
3 IgG and IgM Immunohistochemistry in Primary Biliary Cholangitis (PBC) and Autoimmune Hepatitis (AIH) Liver Explants

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