| General Information of Drug Metabolite (DM) (ID: DM019525) |
| DM Name |
LN2G
|
|
|
|
|
|
|
|
| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
UDP-glucuronosyltransferase 1A1 (UGT1A1)
|
DME0004
|
| Unclear - Unclear |
Losartan
|
[1] |
|
UDP-glucuronosyltransferase 1A3 (UGT1A3)
|
DME0041
|
| Unclear - Unclear |
Losartan
|
[1] |
|
UDP-glucuronosyltransferase 2B7 (UGT2B7)
|
DME0040
|
| Unclear - Unclear |
Losartan
|
[1] |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Full List of Drug(s) That Produce This DM By Metabolism |
| Losartan |
DR3391
|
Phase 3 |
Hypertension |
|
|
| References |
| 1 |
The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol. 2008 Sep 15;76(6):763-72.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
