Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM019993)
DM Name	Edoxaban metabolite M5

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Edoxaban	Unclear - Unclear	Edoxaban	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Edoxaban	Unclear - Unclear	Edoxaban	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Edoxaban		DR0558	Approved		Atrial fibrillation

References
1	Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans Drug Metab Dispos. 2012 Dec;40(12):2250-5. doi: 10.1124/dmd.112.046888.

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