Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000121)
DM Name	3-O-methyl dobutamine

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Catechol O-methyltransferase (COMT)	DME0043	Dobutamine hydrochloride	Conjugation - Methylation	Dobutamine hydrochloride	[1] , [2] , [3]

Full List of Drug(s) That Produce This DM By Metabolism
Dobutamine hydrochloride		DR1758	Approved		Congestive heart failure

References
1	Catechol-O-methyltransferase: substrate-specificity and stereoselectivity for beta-adrenoceptor agents. Xenobiotica. 1986 Jan;16(1):47-52.
2	3-O-methyldobutamine, a major metabolite of dobutamine in humans Drug Metab Dispos. 2002 May;30(5):519-24. doi: 10.1124/dmd.30.5.519.
3	LABEL:OBUTAMINE HYDROCHLORIDE IN DEXTROSE- dobutamine hydrochloride injection

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