Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000218)
DM Name	N-hydroxy lapatinib

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Lapatinib ditosylate	Oxidation - N-Hydroxylation	Lapatinib ditosylate	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Lapatinib ditosylate	Oxidation - N-Hydroxylation	Lapatinib ditosylate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Lapatinib ditosylate		DR0917	Approved		Breast cancer

References
1	Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib Drug Metab Dispos. 2011 Jun;39(6):1022-30. doi: 10.1124/dmd.110.037531.

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