| General Information of Drug Metabolite (DM) (ID: DM000434) |
| DM Name |
5,6-ortho-quinone
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2D6 (CYP2D6)
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DME0009
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| Hydrolysis - Hydrolysis |
Tafenoquine
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Tafenoquine |
DR1526
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Approved |
Malaria |
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| References |
| 1 |
Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial Malar J. 2016 Feb 18;15:97. doi: 10.1186/s12936-016-1145-5.
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| 2 |
Tafenoquine and its potential in the treatment and relapse prevention of Plasmodium vivax malaria: the evidence to date. Drug Des Devel Ther. 2016 Jul 26;10:2387-99.
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