Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000512)
DM Name	Terbinafine dihydrodiol derivative (2)

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Terbinafine hydrochloride	Oxidation - Dihydroxylation	Terbinafine hydrochloride	[1]
Cytochrome P450 2B6 (CYP2B6)	DME0020	Terbinafine hydrochloride	Oxidation - Dihydroxylation	Terbinafine hydrochloride	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Terbinafine hydrochloride	Oxidation - Dihydroxylation	Terbinafine hydrochloride	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	N-Desmethylterbinafine dihydrodiol derivative (2)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]
Cytochrome P450 2B6 (CYP2B6)	DME0020	N-Desmethylterbinafine dihydrodiol derivative (2)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]
Cytochrome P450 2C8 (CYP2C8)	DME0018	N-Desmethylterbinafine dihydrodiol derivative (2)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	N-Desmethylterbinafine dihydrodiol derivative (2)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	N-Desmethylterbinafine dihydrodiol derivative (2)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	N-Desmethylterbinafine dihydrodiol derivative (2)	Oxidation - N-Demethylation	Terbinafine hydrochloride	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Terbinafine hydrochloride		DR1557	Approved		Pityriasis versicolor

References
1	Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.

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