Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000645)
DM Name	5-({[(1R)-1-(4-fluorophenyl)-2-hydroxyethyl]amino}methyl)-2,3-dihydro-1H-1,2,4-triazol-3-one

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Aprepitant	Oxidation - O-Dealkylation	Aprepitant	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Aprepitant	Oxidation - O-Dealkylation	Aprepitant	[1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Aprepitant	Oxidation - O-Dealkylation	Aprepitant	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Aprepitant		DR0125	Approved		Functional nausea/vomiting

References
1	Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92.
2	Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients. Cancer Chemother Pharmacol. 2005 Jun;55(6):609-16.

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