Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM001222)
DM Name	N-Dealkylated perphenazine

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Perphenazine	Oxidation - N-Dealkylation	Perphenazine	[1]
Cytochrome P450 2C8 (CYP2C8)	DME0018	Perphenazine	Oxidation - N-Dealkylation	Perphenazine	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Perphenazine	Oxidation - N-Dealkylation	Perphenazine	[1]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Perphenazine	Oxidation - N-Dealkylation	Perphenazine	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Perphenazine	Oxidation - N-Dealkylation	Perphenazine	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Perphenazine	Oxidation - N-Dealkylation	Perphenazine	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Perphenazine		DR1264	Approved		Schizophrenia

References
1	Anti-Parkinson's disease drugs and pharmacogenetic considerations Expert Opin Drug Metab Toxicol. 2013 Jul;9(7):859-74. doi: 10.1517/17425255.2013.789018.

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