| General Information of Drug Metabolite (DM) (ID: DM002239) |
| DM Name |
Nintedanib metabolite M5
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 1A1 (CYP1A1)
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DME0006
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| Oxidation - Demethylation |
Nintedanib esylate
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Nintedanib esylate |
DR1163
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Approved |
Idiopathic pulmonary fibrosis |
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| References |
| 1 |
Metabolic pro?ling of tyrosine kinase inhibitor nintedanib using metabolomics J Pharm Biomed Anal. 2020 Feb 20;180:113045. doi: 10.1016/j.jpba.2019.113045.
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