| General Information of Drug Metabolite (DM) (ID: DM003224) |
| DM Name |
INCB-024360 Metabolite M12
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 1A2 (CYP1A2)
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DME0003
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| Oxidation - N-dealkylation |
INCB-024360
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - N-dealkylation |
INCB-024360
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[1] |
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME0021
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| Oxidation - N-dealkylation |
INCB-024360
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| INCB-024360 |
DR1874
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Phase 3 |
Renal cell carcinoma |
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| References |
| 1 |
Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans
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