Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM004053)
DM Name	6-O-benzyl-8-oxoguanine

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Aldehyde oxidase (AOX1)	DME0052	O-Benzylguanine	Oxidation - Oxidationn	O-Benzylguanine	[1]
Cytochrome P450 1A1 (CYP1A1)	DME0006	O-Benzylguanine	Oxidation - Oxidationn	O-Benzylguanine	[1]
Cytochrome P450 1A2 (CYP1A2)	DME0003	O-Benzylguanine	Oxidation - Oxidationn	O-Benzylguanine	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	O-Benzylguanine	Oxidation - Oxidationn	O-Benzylguanine	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Aldehyde oxidase (AOX1)	DME0052	8-oxoguanine	Oxidation - Debenzylation	O-Benzylguanine	[1]
Cytochrome P450 1A1 (CYP1A1)	DME0006	8-oxoguanine	Oxidation - Debenzylation	O-Benzylguanine	[1]
Cytochrome P450 1A2 (CYP1A2)	DME0003	8-oxoguanine	Oxidation - Debenzylation	O-Benzylguanine	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	8-oxoguanine	Oxidation - Debenzylation	O-Benzylguanine	[1]

Full List of Drug(s) That Produce This DM By Metabolism
O-Benzylguanine		DR0022	Investigative		Discovery agent

References
1	Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation. Clin Cancer Res. 2001 Dec;7(12):4239-44.

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