| General Information of Drug Metabolite (DM) (ID: DM004138) |
| DM Name |
ABT-001 Metabolite M-
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2C8 (CYP2C8)
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DME0018
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| Other reaction - Methylhydroxylation |
ABT-001
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[1] , [2] |
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Cytochrome P450 2C9 (CYP2C9)
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DME0019
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| Other reaction - Methylhydroxylation |
ABT-001
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[1] , [2] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Other reaction - Methylhydroxylation |
ABT-001
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[1] , [2] |
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME0021
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| Other reaction - Methylhydroxylation |
ABT-001
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| ABT-001 |
DR1474
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Discontinued |
Asthma |
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| References |
| 1 |
Identification of cytochromes P450 involved in the human liver microsomal metabolism of the thromboxane A2 inhibitor seratrodast (ABT-001). Drug Metab Dispos. 1997 Jan;25(1):110-5.
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| 2 |
High-performance liquid chromatographic determination of seratrodast and its metabolites in human serum and urine
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