| General Information of Drug Metabolite (DM) (ID: DM004543) |
| DM Name |
O-Desmethylnaproxen O-glucuronide
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 1A1 (UGT1A1)
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DME0004
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| Conjugation - Glucuronidation |
Naproxen
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[1] |
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UDP-glucuronosyltransferase 1A10 (UGT1A10)
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DME0075
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| Conjugation - Glucuronidation |
Naproxen
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[1] |
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UDP-glucuronosyltransferase 1A7 (UGT1A7)
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DME0065
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| Conjugation - Glucuronidation |
Naproxen
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[1] |
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UDP-glucuronosyltransferase 1A9 (UGT1A9)
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DME0042
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| Conjugation - Glucuronidation |
Naproxen
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Naproxen |
DR1130
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Approved |
Rheumatoid arthritis |
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| References |
| 1 |
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
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