Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM004972)
DM Name	Abrocitinib M4 metabolite
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2B6 (CYP2B6)	DME0020	PF-04965842	Oxidation - Oxidationn	PF-04965842	[1]
Cytochrome P450 2C9 (CYP2C9)	DME0019	PF-04965842	Oxidation - Oxidationn	PF-04965842	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	PF-04965842	Oxidation - Oxidationn	PF-04965842	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	PF-04965842	Oxidation - Oxidationn	PF-04965842	[1]

Full List of Drug(s) That Produce This DM By Metabolism
PF-04965842		DR3486	Phase 3		Atopic dermatitis

References
1	Validation of enantioseparation and quantitation of an active metabolite of abrocitinib in human plasma

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