| General Information of Drug Metabolite (DM) (ID: DM005144) |
| DM Name |
O-des-methyl-pemigatinib
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Unclear - Unclear |
Pemigatinib
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Pemigatinib |
DR5951
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Approved |
Hepatocellular carcinoma |
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| References |
| 1 |
Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A
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