Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM005177)
DM Name	10-O-glucuronyl-SN-38

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DME0004	SN-38	Conjugation - O-gluccuronidation	Sacituzumab govitecan	[1]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DME0042	SN-38	Conjugation - O-gluccuronidation	Sacituzumab govitecan	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Sacituzumab govitecan		DR5914	Approved		Discovery agent

References
1	New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9

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