| General Information of Drug Metabolite (DM) (ID: DM005381) |
| DM Name |
O-Desmethylarformoterol
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2D6 (CYP2D6)
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DME0009
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| Oxidation - O-dealkylation |
Arformoterol
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[1] , [2] , [3] |
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME0021
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| Oxidation - O-dealkylation |
Arformoterol
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[1] , [2] , [3] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Arformoterol |
DR0131
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Approved |
Chronic obstructive pulmonary disease |
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| References |
| 1 |
A simplified procedure for the analysis of formoterol in human urine by liquid chromatography-electrospray tandem mass spectrometry: application to the characterization of the metabolic profile and stability of formoterol in urine
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| 2 |
Mass balance and metabolism of [(3)H]Formoterol in healthy men after combined i.v. and oral administration-mimicking inhalation Drug Metab Dispos. 1999 Oct;27(10):1104-16.
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| 3 |
Current pharmacogenomic recommendations in chronic respiratory diseases: Is there a biomarker ready for clinical implementation?
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