Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM005652)
DM Name	N-desmethyl BDQ (M1)

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2C8 (CYP2C8)	DME0018	Bedaquiline fumarate	Oxidation - N-demethylation	Bedaquiline fumarate	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Bedaquiline fumarate	Oxidation - N-demethylation	Bedaquiline fumarate	[1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Bedaquiline fumarate	Oxidation - N-demethylation	Bedaquiline fumarate	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Bedaquiline fumarate		DR0182	Approved		Pulmonary tuberculosis

References
1	Bedaquiline metabolism: enzymes and novel metabolites. Drug Metab Dispos. 2014 May;42(5):863-6.
2	Effects of Rifamycin Coadministration on Bedaquiline Desmethylation in Healthy Adult Volunteers

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