| General Information of Drug Metabolite (DM) (ID: DM006018) |
| DM Name |
5-chloro-N-ethyl-4-hydroxy-N-(4-hydroxyphenyl)-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
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| PubChem CID |
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Aromatic hydroxylation |
TV-5600
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| TV-5600 |
DR0918
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Phase 3 |
Lupus erythematosus |
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| References |
| 1 |
Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator. Drug Metab Dispos. 2005 Jun;33(6):866-72.
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