Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM006092)
DM Name	Hydrolytic-deaminated clofazimine
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Clofazimine	Hydrolysis - Hydrolytic Deamination	Clofazimine	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Clofazimine	Hydrolysis - Hydrolytic Deamination	Clofazimine	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DME0041	Hydrolytic-deaminated clofazimine glucuronide	Conjugation - Glucuronidation	Clofazimine	[1]
UDP-glucuronosyltransferase 1A4 (UGT1A4)	DME0048	Hydrolytic-deaminated clofazimine glucuronide	Conjugation - Glucuronidation	Clofazimine	[1]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DME0042	Hydrolytic-deaminated clofazimine glucuronide	Conjugation - Glucuronidation	Clofazimine	[1]
UDP-glucuronosyltransferase 2B4 (UGT2B4)	DME0047	Hydrolytic-deaminated clofazimine glucuronide	Conjugation - Glucuronidation	Clofazimine	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Clofazimine		DR0346	Approved		Crohn disease

References
1	Characterization of Clofazimine Metabolism in Human Liver Microsomal Incubation In Vitro

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