Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM006171)
DM Name	Ether glucuronide dolutegravir (M2)

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DME0004	Dolutegravir sodium	Conjugation - Glucuronidation	Dolutegravir sodium	[1]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DME0041	Dolutegravir sodium	Conjugation - Glucuronidation	Dolutegravir sodium	[1]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DME0042	Dolutegravir sodium	Conjugation - Glucuronidation	Dolutegravir sodium	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Dolutegravir sodium		DR0526	Approved		Human immunodeficiency virus infection

References
1	Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans

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