| General Information of Drug Metabolite (DM) (ID: DM006853) |
| DM Name |
Sennidins
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
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Beta-glucosidase (bglA)
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DME1043
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| Unclear - Unclear |
DB-041901
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| DB-041901 |
DR2206
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Phase 2 |
Opioid-induced constipation |
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| References |
| 1 |
Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract
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