General Information of Drug Metabolite (DM) (ID: DM006886)
DM Name
SN-38G
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004 Conjugation - Glucuronidation SN-38 [1] , [2]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME0065 Conjugation - Glucuronidation SN-38 [1] , [2]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Conjugation - Glucuronidation SN-38 [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
SN-38 DR0024 Phase 2 Colorectal cancer
References
1 Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
2 Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.