Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM016999)
DM Name	GS-56650

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Carboxylesterase 1 (CES1)	DME0054	Sofosbuvir	Unclear - Unclear	Sofosbuvir	[1] , [2]
Cathepsin A (CTSA)	DME0071	Sofosbuvir	Unclear - Unclear	Sofosbuvir	[1] , [2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Adenosine 5'-monophosphoramidase (HINT1)	DME0215	GS-606965	Unclear - Unclear	Sofosbuvir	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Sofosbuvir		DR1495	Approved		Viral hepatitis

References
1	Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects
2	Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.

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