Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM017027)
DM Name	Loxoprofen gel metabolite M3

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Loxoprofen gel	Unclear - Unclear	Loxoprofen gel	[1] , [2]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Loxoprofen gel	Unclear - Unclear	Loxoprofen gel	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Loxoprofen gel		DR5328	Approved		Inflammation

References
1	Identification of sulfonyl-loxoprofen as novel phase 2 conjugate in rat
2	Exploring the metabolism of loxoprofen in liver microsomes: the role of cytochrome P450 and UDP-glucuronosyltransferase in its biotransformation. Pharmaceutics. 2018 Aug 2;10(3). pii: E112.

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