Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM017030)
DM Name	Reduced tiaprofenic acid
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Aldo-keto reductase 1A1 (AKR1A1)	DME0098	Tiaprofenic acid	Reduction - Reduction	Tiaprofenic acid	[1]
Aldo-keto reductase 1C4 (AKR1C4)	DME0198	Tiaprofenic acid	Reduction - Reduction	Tiaprofenic acid	[1]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DME0199	Tiaprofenic acid	Reduction - Reduction	Tiaprofenic acid	[1]
NADPH-dependent carbonyl reductase 1 (CBR1)	DME0067	Tiaprofenic acid	Reduction - Reduction	Tiaprofenic acid	[1]
Small intestine reductase (AKR1B10)	DME0398	Tiaprofenic acid	Reduction - Reduction	Tiaprofenic acid	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Tiaprofenic acid		DR5260	Approved		Pain

References
1	Reductive metabolism of tiaprofenic acid by the human liver and recombinant carbonyl reducing enzymes

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