| General Information of Drug Metabolite (DM) (ID: DM017225) |
| DM Name |
LJN452 metabolite M11.6
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Multi-steps Reaction - Oxidative; O-dealkylation |
LJN452
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| LJN452 |
DR3268
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Phase 2 |
Primary biliary cholangitis |
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| References |
| 1 |
Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism
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