| General Information of Drug Metabolite (DM) (ID: DM017228) |
| DM Name |
LJN452 metabolite M22
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 1A1 (UGT1A1)
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DME0004
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| Conjugation - Glucuronidation |
LJN452
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[1] |
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UDP-glucuronosyltransferase 1A3 (UGT1A3)
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DME0041
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| Conjugation - Glucuronidation |
LJN452
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[1] |
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UDP-glucuronosyltransferase 1A7 (UGT1A7)
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DME0065
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| Conjugation - Glucuronidation |
LJN452
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[1] |
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UDP-glucuronosyltransferase 1A9 (UGT1A9)
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DME0042
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| Conjugation - Glucuronidation |
LJN452
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| LJN452 |
DR3268
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Phase 2 |
Primary biliary cholangitis |
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| References |
| 1 |
Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism
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