| General Information of Drug Metabolite (DM) (ID: DM017607) |
| DM Name |
Sotorasib Metabolite M30
|
| Structure |
|
|
3D MOL is unavailable
|
2D MOL is unavailable
|
|
|
|
|
|
|
|
| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Cytosol aminopeptidase (LAP3)
|
DME0569
|
| Hydrolysis - Hydrolysis |
Sotorasib
|
[1] , [2] |
|
Gamma-glutamyltranspeptidase 5 (GGT5)
|
DME0432
|
| Hydrolysis - Hydrolysis |
Sotorasib
|
[1] , [2] |
|
|
|
|
|
|
|
| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
|
Bleomycin hydrolase (BLMH)
|
DME0086
|
| Hydrolysis - Hydrolysis |
Sotorasib
|
[1] |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Full List of Drug(s) That Produce This DM By Metabolism |
| Sotorasib |
DR3515
|
Phase 3 |
Lung cancer |
|
|
| References |
| 1 |
Absorption, Distribution, Metabolism, and Excretion of [(14)C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism
|
| 2 |
Absorption, metabolism and excretion of [(14)C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
