| General Information of Drug Metabolite (DM) (ID: DM018023) |
| DM Name |
Alpelisib Metabolite M3
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Oxidation |
Alpelisib
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Alpelisib |
DR0074
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Approved |
Breast cancer |
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| References |
| 1 |
Absorption, distribution, metabolism, and excretion of [(14)C]BYL719 (alpelisib) in healthy male volunteers. Cancer Chemother Pharmacol. 2015 Oct;76(4):751-60.
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