Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM018033)
DM Name	Mono-N-desethylamiodarone
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A1 (CYP1A1)	DME0006	Amiodarone hydrochloride	Oxidation - N-dealkylation	Amiodarone hydrochloride	[1] , [2] , [3]
Cytochrome P450 2C8 (CYP2C8)	DME0018	Amiodarone hydrochloride	Oxidation - N-dealkylation	Amiodarone hydrochloride	[1] , [2] , [3]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Amiodarone hydrochloride	Oxidation - N-dealkylation	Amiodarone hydrochloride	[1] , [2] , [3]

Full List of Drug(s) That Produce This DM By Metabolism
Amiodarone hydrochloride		DR0093	Approved		Ventricular tachyarrhythmia

References
1	Determination of the cardiac drug amiodarone and its N-desethyl metabolite in sludge samples
2	Amiodarone and concurrent antiretroviral therapy: a case report and review of the literature
3	The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59.

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