Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM018043)
DM Name	(E)-10-hydroxyamitriptyline

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2D6 (CYP2D6)	DME0009	Amitriptyline hydrochloride	Unclear - Unclear	Amitriptyline hydrochloride	[1] , [2]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 2D6 (CYP2D6)	DME0009	(E)-10-hydroxynortriptyline	Unclear - Unclear	Amitriptyline hydrochloride	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Amitriptyline hydrochloride		DR0095	Approved		Depression

References
1	CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies
2	Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.