| General Information of Drug Metabolite (DM) (ID: DM018378) |
| DM Name |
MP
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Adenosine kinase (ADK)
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DME0448
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| Conjugation - Mono-phosphorylation |
Ribavirin
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[1] , [2] , [3] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Ribavirin |
DR1413
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Approved |
Viral hepatitis |
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| References |
| 1 |
Pharmacokinetics and metabolism of [(14)C]ribavirin in rats and cynomolgus monkeys
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| 2 |
Sofosbuvir and Ribavirin Liver Pharmacokinetics in Patients Infected with Hepatitis C Virus
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| 3 |
Adenosine kinase is a key determinant for the anti-HCV activity of ribavirin
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