Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM019454)
DM Name	M409-1

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2D6 (CYP2D6)	DME0009	Fruquintinib	Unclear - Unclear	Fruquintinib	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Fruquintinib	Unclear - Unclear	Fruquintinib	[1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Fruquintinib	Unclear - Unclear	Fruquintinib	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Fruquintinib		DR3419	Phase 3		Solid tumour/cancer

References
1	Esophageal bezoar due to karaya gum granules used as a laxative
2	Preclinical pharmacokinetics and disposition of a novel selective VEGFR inhibitor fruquintinib (HMPL-013) and the prediction of its human pharmacokinetics

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