Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1747)
Drug Name
Amifampridine
Synonyms
Amifampridine; Diamino-3,4 pyridine; Diamino-3,4-Pyridine; Firdapse; OYTKINVCDFNREN-UHFFFAOYSA-N; Pyridine, 3,4-diamino-; RU4S6E2G0J; amifampridin; pyridine-3,4-diamine; 3,4-DAP; 3,4-DIAMINOPYRIDINE; 3,4-Diaminopyridine, 98%; 3,4-Pyridinediamine; 3-amino-4-pyridinylamine; 4,5-Diaminopyridine; 54-96-6; 54-96-6 3,4-diaminopyridine; BRN 0110232; CAS-54-96-6; CHEMBL354077; DSSTox_CID_26715; DSSTox_GSID_46715; DSSTox_RID_81847; EINECS 200-220-9; MFCD00006401; NCGC00167560-01; NSC 521760; SC10; SMR000752913; UNII-RU4S6E2G0J; WT559; Zenas
Indication Lambert-Eaton syndrome [ICD11: 8C62] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 109.13 Topological Polar Surface Area 64.9
Heavy Atom Count 8 Rotatable Bond Count 0
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
5918
ChEBI ID
CHEBI:135948
CAS Number
54-96-6
TTD Drug ID
D0HE0Y
Formula
C5H7N3
Canonical SMILES
C1=CN=CC(=C1N)N
InChI
1S/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8)
InChIKey
OYTKINVCDFNREN-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
3-N-acetylamifampridine DM000860 N. A. Conjugation - Acetylation 1 [2] , [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR000165 Amifampridine 3-N-acetylamifampridine Conjugation - Acetylation NAT2 ... [2], [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
N-acetyltransferase 1 (NAT1) DME0050 Homo sapiens
ARY1_HUMAN
2.3.1.5
[2]
N-acetyltransferase 2 (NAT2) DME0051 Homo sapiens
ARY2_HUMAN
2.3.1.5
[2]
References
1 Amifampridine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphate. Pharmacol Res Perspect. 2015 Feb;3(1):e00099.
3 Investigation of N-Acetyltransferase 2-Mediated Drug Interactions of Amifampridine: In Vitro and In Vivo Evidence of Drug Interactions with Acetaminophen. Pharmaceutics. 2023 May 11;15(5):1471. doi: 10.3390/pharmaceutics15051471.

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