Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2094)
Drug Name
GDP-alpha-D-glucose
Synonyms
GDP-D-glucose; GDP-alpha-D-glucose; GDP-alpha-delta-glucose; GDP-glucose; Guanosine 5-pyrophosphate; Guanosine diphosphate glucose; Guanosine diphosphoglucose; P-alpha-D-glucopyranosyl ester; ZINC8215895; (GDP-Glc)1; 5750-57-2; AC1LD8KB; CHEBI:62254; CHEMBL228228; GDG; GDPG; Guanosine 5'-(trihydrogen diphosphate), P'-alpha-D-glucopyranosyl ester; Guanosine 5-(trihydrogen diphosphate); P-alpha-delta-glucopyranosyl ester; guanosine 5'-[3-(alpha-D-glucopyranosyl) dihydrogen diphosphate]
Indication Discovery agent Investigative [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 605.3 Topological Polar Surface Area 327
Heavy Atom Count 39 Rotatable Bond Count 9
Hydrogen Bond Donor Count 10 Hydrogen Bond Acceptor Count 18
Cross-matching ID
PubChem CID
135398625
ChEBI ID
CHEBI:62254
CAS Number
5750-57-2
Formula
C16H25N5O16P2
Canonical SMILES
C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OC4C(C(C(C(O4)CO)O)O)O)O)O)N=C(NC2=O)N
InChI
1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5-,7-,8-,9+,10-,11-,14-,15-/m1/s1
InChIKey
MVMSCBBUIHUTGJ-LRJDVEEWSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
GDP DM005895
135398619
Unclear 1 [1]
Glucose-1-phosphate DM004098
65533
Unclear 1 [1]
Glucogen DM005865 N. A. Unclear 2 [2] , [3]
Glucose-6-phosphate DM004099
5958
Unclear 2 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006324 GDP-alpha-D-glucose D-glucose 1-phosphate Unclear GHP [1]
MR006327 GDP-alpha-D-glucose GDP Unclear GHP [1]
MR006325 D-glucose 1-phosphate Glucogen Unclear Unclear [2], [3]
MR006326 D-glucose 1-phosphate Glucose-6-phosphate Unclear PGM2 [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
GDP-D-glucose phosphorylase 1 (GDPGP1) DME0469 Homo sapiens
GDPP1_HUMAN
2.7.7.78
[1]
GDP-hexose phosphorylase (GHP) DMEN297 Homo sapiens Not Available Not Available [1]
Phosphoglucomutase 2 (PGM2) DMEN317 Saccharomyces cerevisiae
PGM2_YEAST
5.4.2.2
[2]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
GDP-D-glucose phosphorylase 1 (GDPGP1) DME0469 Km = 0.002 microM
GDPP1_HUMAN
[]
References
1 A Novel GDP-d-glucose Phosphorylase Involved in Quality Control of the Nucleoside Diphosphate Sugar Pool in Caenorhabditis elegans and Mammals. J Biol Chem. 2011 Jun 17;286(24):21511-23.
2 Intracellular glucose 1-phosphate and glucose 6-phosphate levels modulate Ca2+ homeostasis in Saccharomyces cerevisiae
3 UDP-glucose pyrophosphorylase influences polysaccharide synthesis, cell wall components, and hyphal branching in Ganoderma lucidum via regulation of the balance between glucose-1-phosphate and UDP-glucose

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