Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2152)
Drug Name
Xylose
Synonyms
Xylomed; Xylopyranoside; Xylose (USP); Xyloside; D-(+)-Xylose, > D-Xylopyranose; D-Xylopyranoside; D-Xylose; D-xylopentose; D-xylose; MolPort-003-934-029; Xylo-Pfan (TN); cid_135191; (3R,4S,5R)-Tetrahydro-2H-pyran-2,3,4,5-tetraol; (3R,4S,5R)-oxane-2,3,4,5-tetrol; (3R,4S,5R)-tetrahydro-2H-pyran-2,3,4,5-tetrol; 10257-31-5; 7261-26-9; AC1L35YW; BDBM16234; CHEBI:53455; CHEMBL502135; CTK0H1735; D-Xyl; DSSTox_CID_3745; DSSTox_GSID_23745; DSSTox_RID_77180; DTXSID0023745; Epitope ID:114701; MLS001361339; SCHEMBL39891; Xyl
Indication Malabsorption syndrome [ICD11: DA96] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 150.13 Topological Polar Surface Area 90.2
Heavy Atom Count 10 Rotatable Bond Count 0
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
135191
ChEBI ID
CHEBI:53455
CAS Number
50855-32-8
TTD Drug ID
D07HZY
Formula
C5H10O5
Canonical SMILES
C1C(C(C(C(O1)O)O)O)O
InChI
1S/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3+,4-,5?/m1/s1
InChIKey
SRBFZHDQGSBBOR-IOVATXLUSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Xylitol DM005324
6912
Reduction - Reduction 1 [2]
D-Xylulose DM005325
5289590
Oxidation - Oxidationn 2 [2]
Xylulose-5-P DM003850
439190
Conjugation - Phosphorylation 3 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR013275 Xylose Xylitol Reduction - Reduction DCXR [2]
MR013276 Xylitol D-Xylulose Oxidation - Oxidationn SORD [2]
MR013277 D-Xylulose D-Xylulose-5-phosphate Conjugation - Phosphorylation XYLB [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
L-xylulose reductase(DCXR) DMEN891 .
DCXR_HUMAN
1.1.1.10
[2]
Methylenetetrahydrofolate reductase (MTHFR) DME0083 Homo sapiens
MTHR_HUMAN
1.5.1.20
[2]
Sorbitol dehydrogenase (SORD) DME0578 Homo sapiens
DHSO_HUMAN
1.1.1.14
[2]
Xylose isomerase (xylA) DME1164 Bifidobacterium adolescentis
XYLA_BIFAA
5.3.1.5
[3]
Xylose isomerase (xylA) DME1694 Alistipes indistinctus
A0A358M0K8_9BACT
5.3.1.5
[4]
Xylulose kinase (XYLB) DME0526 Homo sapiens
XYLB_HUMAN
2.7.1.17
[2]
⏷ Show the Full List of 6  DME(s)
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Xylose isomerase (xylA) DME1164 Km = 4000 microM
XYLA_BIFAA
[3]
References
1 Xylose was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Metabolism of glucose and xylose as single and mixed feed in Debaryomyces nepalensis NCYC 3413: production of industrially important metabolites
3 Purification and characterization of D-xylose isomerase from Bifidobacterium adolescentis. Biosci Biotechnol Biochem. 1994 Apr;58(4):691-4.
4 Bacterial xylose isomerases from the mammal gut Bacteroidetes cluster function in Saccharomyces cerevisiae for effective xylose fermentation. Microb Cell Fact. 2015 May 17;14:70.

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