Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2723)
Drug Name
Glypromate
Synonyms
Glypromate; Glycyl-prolyl-glutamic acid; Gly-Pro-Glu, >=98% (HPLC); Gly-pro-glu; SCHEMBL1170125; ZINC3776571; ZYK4RVV5LS; glycyl-l-prolyl-l-glutamic acid; 32302-76-4; CHEMBL371315; DB05633; DTXSID80186038; UNII-ZYK4RVV5LS
Indication Epilepsy [ICD11: 8A60] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 301.3 Topological Polar Surface Area 150
Heavy Atom Count 21 Rotatable Bond Count 7
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
3080768
CAS Number
32302-76-4
Formula
C12H19N3O6
Canonical SMILES
C1CC(N(C1)C(=O)CN)C(=O)NC(CCC(=O)O)C(=O)O
InChI
1S/C12H19N3O6/c13-6-9(16)15-5-1-2-8(15)11(19)14-7(12(20)21)3-4-10(17)18/h7-8H,1-6,13H2,(H,14,19)(H,17,18)(H,20,21)/t7-,8-/m0/s1
InChIKey
JJGBXTYGTKWGAT-YUMQZZPRSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Cycloprolylglycine (cPG) DM004208 N. A. Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR004599 Glypromate Cycloprolylglycine (cPG) Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Tripeptidase (pepT) DME1008 Lactococcus lactis
PEPT_LACLL
3.4.11.4
[2]
References
1 Tag Archives: Glypromate.
2 Tripeptidase gene (pepT) of Lactococcus lactis: molecular cloning and nucleotide sequencing of pepT and construction of a chromosomal deletion mutant. J Bacteriol. 1994 May;176(10):2854-61.
3 Improvement in inflammation is associated with the protective effect of Gly-Pro-Glu and cycloprolylglycine against A-induced depletion of the hippocampal somatostatinergic system

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