Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2978)
Drug Name
Pyrazinoylguanidine
Synonyms PZG
Indication Diabetic complication [ICD11: 5A2Y] Discontinued in Phase 2 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 165.15 Topological Polar Surface Area 107
Heavy Atom Count 12 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
124704
CAS Number
60398-24-5
TTD Drug ID
D0W9PG
Formula
C6H7N5O
Canonical SMILES
C1=CN=C(C=N1)C(=O)N=C(N)N
InChI
InChI=1S/C6H7N5O/c7-6(8)11-5(12)4-3-9-1-2-10-4/h1-3H,(H4,7,8,11,12)
InChIKey
WNBSDCKJFDZMHT-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
PZA DM000472
1047
Unclear - Unclear 1 [2]
2-Pyrazinuric acid DM017787 N. A. Oxidation - C11-hydroxylation 2 [3]
OHPZA DM015627
10176178
Unclear - Unclear 2 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR009315 Pyrazinoylguanidine PZA Unclear - Unclear Unclear [2]
MR009316 PZA OHPZA Unclear - Unclear Unclear [2]
MR009317 PZA 2-Pyrazinuric acid Oxidation - C11-hydroxylation Unclear [3]
References
1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002279)
2 Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs
3 A bradykinin antagonist inhibits carrageenan edema in rats

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