Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR3999)
Drug Name
Piroximone
Synonyms MDL-19205
Indication Cardiac failure [ICD11: BD10-BD1Z] Discontinued in Phase 3 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 217.22 Topological Polar Surface Area 71.1
Heavy Atom Count 16 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
55263
CAS Number
84490-12-0
TTD Drug ID
D08FOX
Formula
C11H11N3O2
Canonical SMILES
CCC1=C(NC(=O)N1)C(=O)C2=CC=NC=C2
InChI
InChI=1S/C11H11N3O2/c1-2-8-9(14-11(16)13-8)10(15)7-3-5-12-6-4-7/h3-6H,2H2,1H3,(H2,13,14,16)
InChIKey
OQGWJZOWLHWFME-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
isonicotinyl-formamide DM020007
22766400
Unclear 1 [2]
Piroximole DM015668
10376130
Unclear 1 [2]
Motesanib Mx DM001009
5922
Unclear 2 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR013186 Piroximone Piroximole Unclear Unclear [2]
MR013187 Piroximone isonicotinyl-formamide Unclear Unclear [2]
MR013188 isonicotinyl-formamide Isonicotinic acid Unclear Unclear [2]
References
1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000260)
2 Metabolism and pharmacokinetics of the cardiotonic agent piroximone and of its major metabolite in dog

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.