Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR4155)
Drug Name
CZ-48
Prodrug Info CZ-48 is the prodrug of BMS-830216
Synonyms
Camptothecin-20-O-propionate; UNII-4S145C552U; CZ-48; 194414-69-2; 4S145C552U; SF 6A; CZ48; Camptothecin-20(S)-O-propionate; CZ 48; SCHEMBL1618775; CHEMBL124162; DTXSID30173074; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-(1-oxopropoxy)-, (S)-
Indication Lymphoma [ICD11: 2A80-2A86] Phase 1 [1]
Solid tumour/cancer [ICD11: ICD11: 2A00-2F9Z] Phase 1 [2]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 404.4 Topological Polar Surface Area 85.8
Heavy Atom Count 30 Rotatable Bond Count 4
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
9887472
CAS Number
194414-69-2
TTD Drug ID
D0Z5VG
Formula
C23H20N2O5
Canonical SMILES
CCC(=O)O[C@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)CC
InChI
InChI=1S/C23H20N2O5/c1-3-19(26)30-23(4-2)16-10-18-20-14(9-13-7-5-6-8-17(13)24-20)11-25(18)21(27)15(16)12-29-22(23)28/h5-10H,3-4,11-12H2,1-2H3/t23-/m0/s1
InChIKey
YCNIQYLWIPCLNY-QHCPKHFHSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
BMS-830216 DM020044
44539266
Hydrolysis - Hydrolysis 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR014197 CZ48 Camptothecin Hydrolysis - Hydrolysis CES [3]
References
1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT00947739) Phase I and Pharmacology Study of Camptothecin-20-O-Propionate Hydrate (CZ48) in Patients With Solid Tumors or Lymphoma. U.S. National Institutes of Health.
3 Sustained delivery of a camptothecin prodrug - CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity

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