| General Information of Drug (ID:
DR5313) |
| Drug Name |
Tecfidera
|
| Prodrug Info |
Tecfidera is the prodrug of Monomethyl fumarate
|
| Synonyms |
DIMETHYL FUMARATE |
| Indication |
Multiple sclerosis
[ICD11: 8A40]
|
Approved
|
[1]
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| Structure |
|
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|
3D MOL
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2D MOL
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| Pharmaceutical Properties |
Molecular Weight |
144.12 |
Topological Polar Surface Area |
52.6 |
| Heavy Atom Count |
10 |
Rotatable Bond Count |
4 |
| Hydrogen Bond Donor Count |
0 |
Hydrogen Bond Acceptor Count |
4 |
| Cross-matching ID |
- PubChem CID
- 637568
- ChEBI ID
-
- CAS Number
-
- TTD Drug ID
- D0A7MY
- Formula
- C6H8O4
- Canonical SMILES
- COC(=O)/C=C/C(=O)OC
- InChI
- InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+
- InChIKey
- LDCRTTXIJACKKU-ONEGZZNKSA-N
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| The Metabolic Roadmap of This Drug |
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| The Full List of Drug Metabolites (DM) of This Drug |
| DM Name |
DM ID |
PubChem ID |
Reaction |
DM Level |
REF |
|
Monomethyl fumarate
|
DM015452
|
|
Unclear
-
Unclear |
1 |
[2]
,
[3]
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| The Full List of Metabolic Reaction (MR) of This Drug |
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| References |
| 1 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7045).
|
| 2 |
Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice
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| 3 |
Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases
|
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